In order to participate in this study, you must be able to speak and read Dutch fluently. 

The BaxDuo Prevent-HF study is investigating whether baxdrostat and dapagliflozin can help reduce the risk of developing heart failure. BaxDuo Prevent-HF is looking at a combination of two medicines: 1) the investigational drug baxdrostat, and 2) dapagliflozin, an approved medicine for Type 2 Diabetes, kidney disease and heart conditions.

Our kidneys act as a filtration system for our bodies. They remove waste and help maintain the fluid balance in the blood. Baxdrostat and dapagliflozin both work in the kidneys. Aldosterone tells the kidneys to retain salt and fluid, which can raise blood pressure. By lowering aldosterone levels, baxdrostat may help reduce blood pressure.

We believe that these two medicines may work together to lower blood pressure and protect the kidneys better than dapagliflozin alone. One group in the study will receive baxdrostat and dapagliflozin. The other group will receive a placebo (an inactive substance) and dapagliflozin. There is a 50% chance that you will receive the investigational drug baxdrostat.

You will take part in the study for about three years, although this may be slightly longer or shorter depending on when you start. During this time, you will be asked to take two tablets once a day and attend around 15 clinic visits for tests and check-ups to monitor your health. The first six visits will take place every 2 to 8 weeks. After that, all visits will be scheduled every four months until the end of the study.

The study is being conducted in Amsterdam, Den Bosch or Zwolle.
This study is sponsored by AstraZeneca.

You always decide whether you participate in a study. Participation is always voluntary.

1. You apply via the online form, this is non-binding.
2. After application, you are phoned, this is also an opportunity for you to ask questions. During this conversation, we also ask some questions to see whether you are eligible to participate in research. After this conversation, you determine whether you want to progress to step 3.
3. You receive an email with the request to sign a document in which you give permission to retrieve your medical data.
4. When your medical data shows that you meet the requirements to participate in the study, you are invited to a meeting at our location. During this meeting, you receive information and have the opportunity to ask questions, before you decide to participate in research.
5. If you decide to participate in the study, you sign a form and will start the study within several weeks.

1. You always come first – everything we do revolves around you.
2. Experienced team of doctors and nurses.
3. Open and homely atmosphere – this will make you feel relaxed and right at home.
4. Clarity – expert in medicine research which is why you will be well informed during all steps of the process and can always come to us for questions.
5. Always nearby – 3 locations spread through the Netherlands.

• You may experience benefits from a new treatment.
• You will be monitored by a specialized team of healthcare professionals. They can give you advice and monitor whether there is a change in your daily functioning.
• You make a meaningful contribution to better treatment for cardiovascular diseases.
• You contribute to the advancement of science.

You can participate when:

• Type 2 Diabetes, treatment for high blood pressure, a condition affecting the heart or blood vessels
• You are 40 years or older

Are you unsure whether you meet these requirements? Then you can always apply. We will then check together whether you are suitable to participate.